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![Phytochemicals and cancer chemoprevention](https://image.oaes.cc/7c5f835e-c35c-4397-bf06-44a5473ab22f/3784.fig.7.jpg)
Figure 7. The molecular targets of silibinin. Silibinin exhibits a decrease in mitochondrial function and releases mitochondrial cytochrome c. The compound initiates cell death in primary tumor cells and causes up-regulation in p21, p27, and p18, leading to cell-cycle arrest. In addition, autophagy is induced by up-regulation of BAX, Bim, and Beclin-1