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Figure 1. Activation of NK cell using anti-LLT1 monoclonal antibody. (Left) Prostate and triple-negative breast cancer cells express LLT1 which can bind to NKRP1A on NK cells leading to inhibition of NK cell function. (Right) However, in the presence of anti-LLT1 antibodies, NK cells can be activated via two mechanisms: (1) blocking of LLT1 prevents inhibitory signal transmission; and (2) activation when NK cell receptor CD16 binds to anti-LLT1 antibody bound to LLT1 on cancer cells. Image created using BioRender (www.BioRender.com). NK: natural killer; LLT1: lectin-like transcript 1; mAb: monoclonal antibody