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Figure 4. Expression of paxillinS178A impairs lung metastasis formation in vivo. One representative clone of either GFP-paxillin-wt or GFP-paxillinS178A MTLn3 cell-lines were used for in vivo experiments. A: Primary tumors were imaged using two-photon intravital imaging. Scale bar is 100 μm; B: no significant difference in tumor weight was measured between the wt mice (n = 10) and S178A mice (n = 12); C: two-photon intravital microscopy, H&E staining of lung slices; D: quantification of the number of GFP-positive lung metastases demonstrated that paxilinS178A reduced lung metastasis formation. Scale bar is 100 μm