REFERENCES
3. Gangoda L, Keerthikumar S, Fonseka P, Edgington LE, Ang CS, et al. Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin. Oncotarget 2015;6:11175-90.
4. London WB, Castleberry RP, Matthay KK, Look AT, Seeger RC, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group. J Clin Oncol 2005;23:6459-65.
5. Evans AE, D’Angio GJ, Propert K, Anderson J, Hann HWL. Prognostic factors in neuroblastoma. Cancer 1987;59:1853-9.
6. Evans AE, D’Angio GJ, Randolph J. A proposed staging for children with neuroblastoma. Children’s cancer study group A. Cancer 1971;27:374-8.
7. Cheung NKV, Zhang J, Lu C, Parker M, Bahrami A, et al. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA 2012;307:1062-71.
8. Schilling FH, Spix C, Berthold F, Erttmann R, Fehse N, et al. Neuroblastoma screening at one year of age. N Engl J Med 2002;346:1047-53.
9. Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 1993;11:1466-77.
10. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, et al. Association of Multiple Copies of the N-myc Oncogene with Rapid Progression of Neuroblastomas. N Engl J Med 1985;313:1111-6.
11. Oppedal BR, Oien O, Jahnsen T, Brandtzaeg P. N-myc amplification in neuroblastomas: histopathological, DNA ploidy, and clinical variables. J Clin Pathol 1989;42:1148-52.
12. Rubie H, Hartmann O, Michon J, Frappaz D, Coze C, et al. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Société Francaise d’Oncologie Pédiatrique. J Clin Oncol 1997;15:1171-82.
13. Bowman LC, Castleberry RP, Cantor A, Joshi V, Cohn SL, et al. Genetic staging of unresectable or metastatic neuroblastomain infants: a pediatric oncology group study. J Natl Cancer Inst 1997;89:373-80.
14. Chang PCY, Wang NL, Liu HC, Liang DC, Yeh TC, et al. Low-stage pediatric neuroblastoma: a 20-year single institution review. J Cancer Res Pract 2018;5:9-12.
15. Sharma R, Mer J, Lion A, Vik TA. Clinical presentation, evaluation, and management of neuroblastoma. Pediatr Rev 2018;39:194-203.
16. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. N Engl J Med 1999;341:1165-73.
17. Luksch R, Castellani MR, Collini P, De Bernardi B, Conte M, et al. Neuroblastoma (Peripheral neuroblastic tumours). Crit Rev Oncol Hematol 2016;107:163-81.
18. Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME, et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: the childhood cancer survivor study. J Clin Oncol 2001;19:3163-72.
19. Whelan KF, Stratton K, Kawashima T, Waterbor JW, Castleberry RP, et al. Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor study. Pediatr Blood Cancer 2010;54:103-9.
20. Friedman DL, Meadows AT. Late effects of childhood cancer therapy. Pediatr Clin North Am 2002;49:1083-106.
21. Friedman DL, Freyer DR, Levitt GA. Models of care for survivors of childhood cancer. Pediatr Blood Cancer 2006;46:159-68.
22. Nandagopal R, Laverdiere C, Mulrooney D, Hudson MM, Meacham L. Endocrine late effects of childhood cancer therapy: a report from the Children’s Oncology Group. Horm Res 2008;69:65-74.
24. Rose SR, Horne VE, Howell J, Lawson SA, Rutter MM, et al. Late endocrine effects of childhood cancer. Nat Rev Endocrinol 2016;12:319-36.
25. Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, et al. Survival and late effects in children with stage 4 neuroblastoma. Pediatr Blood Cancer 2011;57:629-35.
27. Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009;28:15-33.
28. Jolly MK, Ware KE, Gilja S, Somarelli JA, Levine H. EMT and MET: necessary or permissive for metastasis? Mol Oncol 2017;11:755-69.
29. Yang AD, Fan F, Camp ER, van Buren G, Liu W, et al. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 2006;12:4147-53.
30. Uchibori K, Kasamatsu A, Sunaga M, Yokota S, Sakurada T, et al. Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell lines. Int J Oncol 2012;40:1005-10.
31. Hoshino H, Miyoshi N, Nagai K, Tomimaru Y, Nagano H, et al. Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. Biochem Biophys Res Commun 2009;390:1061-5.
32. Tomeh MA, Hadianamrei R, Zhao X. A review of curcumin and its derivatives as anticancer agents. Int J Mol Sci 2019;20:1033.
33. Raina K, Kumar S, Dhar D, Agarwal R. Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy. J Biomed Res 2016;30:452-65.
34. Bosch-Barrera J, Queralt B, Menendez JA. Targeting STAT3 with silibinin to improve cancer therapeutics. Cancer Treat Rev 2017;58:61-9.
35. Singh RP, Agarwal R. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocr Relat Cancer 2006;13:751-78.
36. Sidhar H, Giri RK. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Sci Rep 2017;7:41420.
37. Namkaew J, Jaroonwitchawan T, Rujanapun N, Saelee J, Noisa P. Combined effects of curcumin and doxorubicin on cell death and cell migration of SH-SY5Y human neuroblastoma cells. In Vitro Cell Dev Biol Anim 2018;54:629-39.
38. Klijn C, Durinck S, Stawiski EW, Haverty PM, Jiang ZS, et al. A comprehensive transcriptional portrait of human cancer cell lines. Nat Biotechnol 2015;33:306-12.
39. Tan TZ, Miow QH, Miki Y, Noda T, Mori S, et al. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med 2014;6:1279-93.
40. Mathivanan S, Ji H, Tauro BJ, Chen YS, Simpson RJ. Identifying mutated proteins secreted by colon cancer cell lines using mass spectrometry. J Proteomics 2012;76:141-9.
41. Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010;70:440-6.
42. Hoffmann H. violin. m-Simple violin plot using matlab default kernel density estimation. Katzenburgweg, Germany: INRES (University of Bonn); 2015.
43. Tan TZ, Miow QH, Miki Y, Noda T, Mori S, et al. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med 2014;6:1279-93.
44. Liang Z, Lu L, Mao J, Li X, Qian H, et al. Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/beta-catenin. Cell Death Dis 2017;8:e3066.
45. Li F, Sun Y, Jia J, Yang C, Tang X, et al. Silibinin attenuates TGFbeta1induced migration and invasion via EMT suppression and is associated with COX2 downregulation in bladder transitional cell carcinoma. Oncol Rep 2018;40:3543-50.
46. Cao L, Xiao X, Lei J, Duan W, Ma Q, et al. Curcumin inhibits hypoxia-induced epithelialmesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. Oncol Rep 2016;35:3728-34.
47. Kim JS, Han NK, Kim SH, Lee HJ. Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition. Oncotarget 2017;8:69386-97.
48. Nakajima S, Doi R, Toyoda E, Tsuji S, Wada M, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 2004;10:4125-33.
49. Veas-Perez de Tudela M, Delgado-Esteban M, Cuende J, Bolanos JP, Almeida A. Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase. J Neurochem 2010;113:819-25.
50. Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003;3:203.
52. Kaczowka P, Wieczorek A, Czogala M, Ksiazek T, Szewczyk K, et al. The role of N-Myc gene amplification in neuroblastoma childhood tumour - single-centre experience. Contemp Oncol (Pozn) 2018;22:223-8.
53. Picone P, Nuzzo D, Caruana L, Messina E, Scafidi V, et al. Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation. Free Radic Res 2014;48:1397-408.
54. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41:40-59.
55. Deep G, Agarwal R. Anti-metastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010;29:447-63.
56. Wang Q, Qu C, Xie F, Chen L, Liu L, et al. Curcumin suppresses epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells by inhibiting cancer-associated fibroblasts. Am J Cancer Res 2017;7:125-33.
57. Ramasamy TS, Ayob AZ, Myint HH, Thiagarajah S, Amini F. Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. Cancer Cell Int 2015;15:96.
58. Kumar S, Raina K, Agarwal C, Agarwal R. Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals. Oncotarget 2014;5:4972-89.
59. Zang S, Liu T, Shi J, Qiao L. Curcumin: a promising agent targeting cancer stem cells. Anticancer Agents Med Chem 2014;14:787-92.
60. Basta NO, Halliday GC, Makin G, Birch J, Feltbower R, et al. Factors associated with recurrence and survival length following relapse in patients with neuroblastoma. Br J Cancer 2016;115:1048-57.
61. London WB, Castel V, Monclair T, Ambros PF, Pearson AD, et al. Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol 2011;29:3286-92.
62. James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, et al. Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy. Cancer Lett 2015;364:135-41.
63. Irving GR, Iwuji CO, Morgan B, Berry DP, Steward WP, et al. Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial. Trials 2015;16:110.
64. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008;14:4491-9.
65. Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, et al. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol 2010;50:434-49.
66. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, et al. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer 2010;116:506-13.
