fig2
![CXCR4 signalling, metastasis and immunotherapy: zebrafish xenograft model as translational tool for anti-cancer discovery](https://image.oaes.cc/fe8de4e2-471f-46e9-98a9-548ddad6deab/3254.fig.2.jpg)
Figure 2. CXCR4 drives the interaction between cancer and stromal cells. The CXCR4-CXCL12 axis signals in a bi-directional fashion. CXCR4 is expressed by both tumour cells and cells that form the surrounding stroma [fibroblast, T cells, T reg cells, myeloid derived suppressors cells (MDSCs), macrophages and neutrophils], embedded in the extracellular matrix (ECM). The CXCR4 cognate ligand CXCL12 is secreted by both cancer cells and cells in the microenvironment