fig2
![Micromanaging autophagy with microRNAs to drive cancer metastasis](https://image.oaes.cc/06494d5a-1d4a-43ef-a15a-a6835b64dd73/3227.fig.2.jpg)
Figure 2. MiRNA inhibition of autophagy during secondary tumor formation. In the colonization process, autophagy is inhibited either by upregulation of anti-autophagy miRNAs, or the downregulation of the pro-autophagy miRNAs. This process promotes the re-establishment of an epithelial cell state for developing into macrometastasis. Upregulated pro-EMT miRNAs are depicted as large red icons, while downregulated pro-MET miRNAs are depicted as small blue icons. EMT: epithelial-to-mesenchymal transition; MET: mesenchymal-to-epithelial transition