fig1
![Micromanaging autophagy with microRNAs to drive cancer metastasis](https://image.oaes.cc/06494d5a-1d4a-43ef-a15a-a6835b64dd73/3227.fig.1.jpg)
Figure 1. MiRNA regulation of autophagy during cancer invasion. The key components of macroautophagy is shown in this diagram. In the invading pro-metastatic cancer cell, autophagy is upregulated by gain of oncomiRs and loss of tumor-suppressive miRNAs. The oncomiRs target the inhibitors of autophagy to increase autophagic flux. The downregulated miRNAs on the other hand, are required for the activation of autophagy. Upregulated pro-EMT miRNAs are depicted as large red icons, while downregulated pro-MET miRNAs are depicted as small blue icons. The miRNA targets and mechanisms of actions are summarized in Table 1. EMT: epithelial-to-mesenchymal transition; oncomiRs: oncogenic miRNAs; MET: mesenchymal-to-epithelial transition