fig5

Figure 5. Analyses of incidence of metastases, and total metastatic load, in nude mice with 4T1 breast tumors. Mice from four different treatment groups [vehicle only, capecitabine (CPBN) only, vehicle + photodynamic therapy (PDT) and CPBN + PDT] were quantitatively analyzed as follows. (A) Incidence of metastases by week 3. Note that the first three treatment groups showed 60%-70% of mice with metastases, whereas the CPBN + PDT treatment group showed only 17% of mice with metastases; (B) metastatic tumor load per mouse, calculated by comparing the cumulative bioluminescence units (BLUs) from each mouse with the average cumulative BLUs from no-PDT controls. The metastatic load of 14% in CPBN + PDT group is much lower than the other three groups (96%-111%)