fig4

Figure 4. Non-histone lysine specific demethylase 1 (LSD1) substrate: hypoxia inducible factor-1 alpha (HIF-1α) protein stability is modulated by LSD1. A: Metylation-demethylation by SET7/9 and LSD1 respectively regulates HIF-1α degradation; B: LSD1-mediated regulation of HIF-1α protein stability during hypoxia: In early stage of hypoxia, the LSD1 (FAD-dependent) demethylase activity protects HIF-1α from RACK1-mediated degradation and HIF-1α activates transcription of its target genes. In prolonged hypoxia, the absence of FAD impairs FAD-dependent LSD1 activity on HIF-1α with consequent RACK1-dependent HIF-1α protein degradation