fig1

Figure 1. Lysine specific demethylase 1 (LSD1) protein domains and structure. A: In orange the SWIRM domain, in green the AOD domains and in yellow the Tower Domain; B: LSD1 selective substrate specificities: LSD1 represses promoter and enhancer activities through the demethylation of histones lysines, H3K4 or in cooperation with the androgen receptor (AR), activates transcription through Histones H3K9 demethylation