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![Targeting histone lysine-specific demethylase KDM1A/LSD1 to control epithelial-mesenchymal transition program in breast cancers](https://image.oaes.cc/b2257013-721a-4515-821b-4f87f3d2c605/2993.fig.1.jpg)
Figure 1. Lysine specific demethylase 1 (LSD1) protein domains and structure. A: In orange the SWIRM domain, in green the AOD domains and in yellow the Tower Domain; B: LSD1 selective substrate specificities: LSD1 represses promoter and enhancer activities through the demethylation of histones lysines, H3K4 or in cooperation with the androgen receptor (AR), activates transcription through Histones H3K9 demethylation