fig2

Figure 2. Coexpression of ADAMTS-1 and fibulin-1 reduces the invasion properties of the breast cancer cell lines MCF-7 and MDA-MB-231. Cell invasion assay using Matrigel-coated invasion chambers. A: representative microscopic pictures of MDA-MB-231 cells expressing exogenous fibulin-1, ADAMTS-1 or both proteins simultaneously. Cells transfected with an empty vector were used as a control. Cells that reached the lower surface were counted and are graphically shown; B: representative microscopic pictures of MCF-7 cells expressing exogenous fibulin-1, ADAMTS-1 or both proteins simultaneously. Cells transfected with an empty vector were used as a control. Cells that reached the lower surface were counted and graphically represented. P values under 0.05 were considered statistically significant (*P < 0.05, **P < 0.01, ***P < 0.005)