fig4
From: Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target
Figure 4. APN-mediated polarisation of macrophages to anti-inflammatory M2 phenotype. Through AdipoR1 and undefined receptors APN causes NF-κB inhibition and promotion of M2 phenotype. Green arrows represent activating pathways. Red lines represent inhibitory pathways. gAcrp: globular adiponectin; flAcrp: full length adiponectin; STAT6: signal transducer and activator of transcription 6; CREB: cAMP response element-binding protein; JNK: c-Jun N-terminal kinase; SOC3: suppressor of cytokine signalling 3; Bcl3: B-cell lymphoma 3-encoded protein; TRAF1: TNF receptor-associated factor 1; TNIP3: TNFAIP3-interacting protein 3; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells
