fig3
From: Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target
Figure 3. AdipoR1 and AdipoR2 mediated tolerance of dendritic cells. APN generates dendritic cell tolerance via two distinct pathways that converge upon NF-κB inhibition. Green arrows represent activating pathways. Red lines represent inhibitory pathways. gAcrp: globular adiponectin; flAcrp: full length adiponectin; AMPK: 5’ APM activated protein kinase; Cox2: cyclooxygenase-2; PPAR-γ: peroxisome proliferator-activated receptor gamma; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; STAT3: signal transducer and activator of transcription 3; SOC3: suppressor of cytokine signalling 3
