fig2

From: Cryptic NUP214-ABL1 fusion with complex karyotype, episomes and intra-tumor genetic heterogeneity in a T-cell lymphoblastic lymphoma

Cryptic <i>NUP214-ABL1</i> fusion with complex karyotype, episomes and intra-tumor genetic heterogeneity in a T-cell lymphoblastic lymphoma

Figure 2. A: Array comparative genomic hybridization (aCGH) analysis of chromosome 6 revealed high level of 6q23.3 amplification containing MYB gene (arrow); B: MYB Dual Color Break Apart Probe was applied and showed high level of amplification more than 20 copies/per cell; C: aCGH analysis of chromosome 9 revealed biallelic deletion of CDKN2A at 9p21.3 and high level of 9q34 amplification contains ABL1 and NUP214 (arrow); D: FISH confirmed the homozygous deletion of CDKN2A in metaphase; E: BCR, ABL Dual Color Probe was applied and showed variable number of episomes (20-30) in spread metaphases. aCGH: array-comparative genomic hybridization; FISH: fluorescence in situ hybridization; wcp: whole chromosome paint