fig5
From: Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity
Figure 5. A model of GBM with TH and CIN in control of tumor recurrence. (A) differential intra- and peri-tumoral distributions of slow-growing invasive STIC and fast growth TMC, and differential CIN rate in the bulk of tumor mass (TM) and parenchyma of peritumoral tissue (PT); (B) recurrent GBM models from Chr7- and DM-defined STIC and TMC based on published studies[13,14]. A thick black arrow shows the proliferation of cells to re-populate, and a thin red arrow shows the proliferation of cells with MS of Chr7- and DM, giving rise to other functional subpopulations
