fig3
From: Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity
Figure 3. Increase in TH in vivo due to decrease of cell inoculum size and inhibition of CIN from overexpression of EFEMP1. (A) comparison of Chr7-subpopulations in xenografts derived from intracranial (i.c.) implantation of U251-NS at various inoculum sizes (1000, 10,000, and 100,000 cells/3 mL); (B) comparison of Chr7-subpopulations in xenografts of U251-NS from various inoculum sizes and with expression of ectopic EFEMP1 induced by treatment with Dox. See for Chr7-defined populations. Bar height and error bar are mean and SD of individual mice. Data from FISH analyses and mice survival were reported in Hu et al.[32]
