fig12
Figure 12. 3D binding mode and interaction of PIK-III (PDB ID: 4PH4) (A), compound 3a (PDB ID: 5ENN) (B), compound 3c (PDB ID: 4UWF) (C) and compound 3f (PDB ID: 4UWL) (D) with Vps34. Hydrogen and water mediated hydrogen bonds are represented in black dotted lines
