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From: Differential expression and function of the endogenous lactate receptor, GPR81, in ERα-positive/HER2-positive epithelial vs. post-EMT triple-negative mesenchymal breast cancer cells

Differential expression and function of the endogenous lactate receptor, GPR81, in ERα-positive/HER2-positive epithelial <i>vs</i>. post-EMT triple-negative mesenchymal breast cancer cells

Figure 2. GPR81 is highly expressed in human hormone-receptor-positive breast cancer tissues. A: relative mRNA expression of GPR81 in ER⁺ (n = 32), HER2⁺ (n = 17) and TNBC (n = 12) breast cancer tissues to normal tissue (n = 12); B: relative mRNA expression of GPR81 in stage I (n = 21), II (n = 32), III (n = 25) and IV (n = 4) of breast cancer; C: Kaplan-Meier plot of estimated overall survival in breast cancer patients (n = 626) with low expression of GPR81, below the median (black line) or high expression of GPR81, above the median (red line). Log-rank test P-value = 0.0011. Results are presented as mean ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001 (two-way ANOVA)