fig50

TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells

Supplementary Figure 5. Post-EMT cells are sensitized to inhibitors against IGF-1R and EGFR. Pre- and post-EMT MCF-7 cells were cultured in the absence (diluent) or presence of AG1024 (10 µmol/L; A) or AG1478 (10 µmol/L; B) for 5 days prior to analyzing differences in cell growth and survival by MTS assays. Data are the mean growth (± SE; n = 3; *P < 0.05; Student's t-test). EMT: epithelial-mesenchymal transition; IGF: insulin-like growth factor; EGFR: epidermal growth factor receptor; SE: standard error

Journal of Cancer Metastasis and Treatment
ISSN 2454-2857 (Online) 2394-4722 (Print)

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