Neuroendocrine tumors: a multidisciplinary approach for a complex disease
Neuroendocrine neoplasms include a heterogeneous group of neoplasms, representing a spectrum of rare neoplasms arising in different organism sites with different malignant potential and behavior. They typically occur in gastrointestinal and bronchopulmonary tracts.
The incidence and prevalence of these neoplasms showed a significant increase in the last four decades leading to a rising interest in these tumours with remarkable progresses in their both treatment and management. Nevertheless, they are still considered rare diseases with a global clinical incidence of 3.65 cases/100,000 per year according to the National Cancer Institute SEER (Surveillance Epidemiology and End Results) registry.[1]
Surgery still remains the primary treatment approach mainly depending on tumour size, stage and patients performance status. However in loco-regional unresectable and/or metastatic disease, curative surgery is generally not possible, therefore medical therapy is usually primarily considered. Several treatment options are available and to date the management of neuroendocrine tumors within clinical practice is based on a multimodal therapeutic strategy including surgery and other loco-regional therapies, somatostatin analogs (SSAs), peptide receptor radionuclide therapy (PRRT), cytotoxic agents, biological agents (including angiogenesis inhibitors such as sunitinib and inhibitors of mammalian target of rapamycin as everolimus) with a multidisciplinary approach.[2]
SSAs, including octreotide and lanreotide, represent effective options in the presence of carcinoid syndrome, but they also have an antiproliferative effect in secreting and nonsecreting neuroendocrine tumors.[3,4]
PRRT is an emerging treatment modality for advanced neuroendocrine tumors. It is performed in the treatment of neuroendocrine tumors, where somatostatin analogues (DOTATOC, DOTATATE) are radiolabeled with 177 Lu, 90 Y, or 111 In for pre-therapeutic and therapeutic purposes.[5]
There are many cumulative evidences about the effectiveness and tolerability of this therapeutic approach, especially in gastro-entero-pancreatic neuroendocrine tumors.
Neuroendocrine neoplasms therapy also includes cytotoxic agents, expecially in symptomatic patients, in progressive disease, in case of moderate or poor differentiation and more aggressive features. Chemotherapy schedules used in this setting include alkylating agents (streptozotocin, dacarbazine, and temozolomide), antimetabolites (5-fluorouracil, capecitabine), etoposide and platinum derivatives (including cisplatin and oxaliplatin).[6]
The availability of new targeted agents, such as everolimus and sunitinib, which are effective in advanced and metastatic pancreatic neuroendocrine tumors, has provided new treatment opportunities.
Despite comprehensive and interesting medical progress, the current available therapeutic options are still inadequate for gastrointestinal and lung neuroendocrine tumors, mainly due to the lack of in-depth knowledge of molecular mechanisms and predictive factors.
Prognostic evaluation is mainly based on their morphologic features and proliferation index, according to WHO classification.[7]
Due to the usually long life-expectancy of these patients, many different lines of therapy are performed according to difference status of the disease as well as on timing. Thus, despite the sequencing of different therapies represents a true challenge in real life, a standard therapeutic sequence is still lacking and it is a matter of debate.
Therefore novel strategies are needed, especially for refractory and/or recurrent neuroendocrine neoplasms that present a poor prognosis. Personalized approaches are currently being developed and molecular targets are emerging.
Several driver pathways have been investigated and they may represent important factors in the carcinogenesis process and, therefore, potential targets for new anticancer therapies.
In particular, activating mutations have been identified several genes, including those of the epidermal growth factor receptor, platelet-derived growth factor receptor, vascular endothelial growth factor, basic-fibroblastic growth factor, transforming growth factor, insulin-like growth factor-1, and their receptors, stem cell factor receptor. New drugs (including immunotherapy) and several combination regimens with new biological agents are being developed and studied in recently conducted and ongoing trials.
Further investigations could increase our knowledge about molecular mechanisms responsible for the neuroendocrine neoplasms heterogeneity, about tumor interactions with adjacent healthy tissue and as regard its variegated response to treatments, to guarantee the development of new promising therapies.
This special issue on neuroendocrine neoplasms aims to summarize the present knowledge about the treatment of these tumors highlighting available evidences as well as new biological perspectives on biological and targeted therapies, also including case reports.
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Conflicts of interest
There are no conflicts of interest.
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How to Cite
Berardi, R. Neuroendocrine tumors: a multidisciplinary approach for a complex disease. J. Cancer. Metastasis. Treat. 2016, 2, 277-8. http://dx.doi.org/10.20517/2394-4722.2016.50
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