fig1
From: Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors
Figure 1. Principal pathways involved in carcinogenesis and progression of NENs. EGFR: epidermal growth factor receptor; VEGFR2: vascular endothelial growth factor receptor 2; IGF1R: insulin-like growth factor 1 receptor; SSTR: somatostatin receptors; SOS: save our souls; PI3K: phosphoinositide 3-kinase; PIP2: phosphatidylinosital biphosphate 2; PIP3: phosphatidylinosital biphosphate 3; PTEN: phosphatase and tensin homolog; MEK: methyl ethyl ketone; ERK: extracellular signal-regulated kinase ; AKT: protein kinase B; mTOR: mammalian target of rapamycin; MAPK: mitogen-activated protein kinase
