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From: Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors
![Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors](https://image.oaes.cc/84f1a3d8-3fcc-4326-a3e9-3feaabcba8d6/1633.fig.1.png)
Figure 1. Principal pathways involved in carcinogenesis and progression of NENs. EGFR: epidermal growth factor receptor; VEGFR2: vascular endothelial growth factor receptor 2; IGF1R: insulin-like growth factor 1 receptor; SSTR: somatostatin receptors; SOS: save our souls; PI3K: phosphoinositide 3-kinase; PIP2: phosphatidylinosital biphosphate 2; PIP3: phosphatidylinosital biphosphate 3; PTEN: phosphatase and tensin homolog; MEK: methyl ethyl ketone; ERK: extracellular signal-regulated kinase ; AKT: protein kinase B; mTOR: mammalian target of rapamycin; MAPK: mitogen-activated protein kinase