fig1

Figure 1. Model of growth, progression and dissemination of primary brain tumors. The progression of primary brain tumors from a small neoplastic lesion to a metastasizing tumor through growth and dissemination of tumor cells is schematically visualized. The mode of tumor cell growth and dissemination varies between different tumors and involves random or guided, single or collective dissemination of tumor cells. The model depicting low range dissemination at early stages and the consequent increased net tumor growth is according Waclaw et al.^[14]