fig1

Figure 1. Urological lesions identified in rats exposed to BBN. (1) hematoxylin and eosin stain; (2) respective molecular alterations. a: Hyp; b: Dysp; c: LGP urothelial carcinoma; d: HGP urothelial carcinoma; e: CIS; f: INV. BBN: N-butyl-N-(4-hydroxybutyl) nitrosamine; Hyp: hyperplasia; Dysp: dysplasia; LGP: low grade papillary; HGP: high grade papillary; CIS: carcinoma in situ; INV: invasive urothelial carcinoma; 5cER: 5c exceeding rate