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From: Changes in human epidermal growth factor receptor 2 status between primary breast/gastric carcinomas and synchronous metastatic lymph nodes: how can we explain them?

Changes in human epidermal growth factor receptor 2 status between primary breast/gastric carcinomas and synchronous metastatic lymph nodes: how can we explain them?

Figure 1. Expression of HER2 protein. A score of 3+ HER2 expression was encountered in neoplastic elements in a primary GC (a, ×200) but vanished in the corresponding metastatic lymph node (negative conversion) (b, ×160) (IHC, Mayer's hematoxylin counterstain). HER2 immunohistochemical negative staining in primary GC (c, ×200), demonstrated a positive reactivity in the metastatic synchronous lymph node (positive conversion) (d, ×200) (IHC, Mayer's hematoxylin counterstain). HER2: Human epidermal growth factor receptor 2; GC: Gastric carcinomas; IHC: Immunohistochemistry

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