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Figure 2. TMR involves the coaptation of amputated nerves (often large mixed motor and sensory nerves) to much smaller intramuscular motor branches. In a trans-humeral amputation, the median nerve is coapted to a musculocutaneous branch. This allows median nerve signals to create an electromyographic signal to facilitate prosthesis control. Clinically, TMR has been found to prevent and treat amputation-related pain. Created in BioRender. Dominguez, E. (2024) BioRender.com/n95n750. TMR: Targeted muscle reinnervation.