fig8

Figure 8. For a detailed description, see the text above. Briefly, 1-at the upper right hand of the image, one sees irradiation energy causing breakup of the TGF-β-Ligand complex with activation of TGF-β. 2- The TGF-β receptor is activated and 3- the SMAD complex initiates nuclear DNA transcription that results in 4 Secretion of various factors that affect various cellular behaviors (a, b, c, d, e, f), culminating in a fibrotic state. 5-When Fat Grafts are injected into the fibrotic tissue, SVF MSCs within the graft release HGF, 6- HGF receptor is activated and 7- the GAB1 intracellular moiety initiates a group of intracellular pathways that constitute the 8- “Mitotic Growth Program” (a, b, c, d, e, f) that in turn causes tissue regeneration and blocks TGF-β actions.