fig7

Understanding how MSCs reverse radiation-induced fibrosis: HGF <i>vs.</i> TGF-B1

Figure 7. (From Liu[28]) Antagonism between HGF and TGF-β in the pathogenesis of renal fibrosis. (A) expression pattern of HGF and TGF-β in the diseased kidney. The duration of injury may determine whether the damaged tissues undergo recovery or fibrogenesis. Transient injury (dashed line) leads to a TGF-β/HGF ratio that favors HGF, resulting in tissue repair and regeneration, whereas chronic injury dramatically changes the TGF-β/ HGF ratio to favor TGF-β, leading to tissue fibrosis; (B) function of TGF-β and HGF in fibrotic kidneys. +: Promoting; -: suppressing; (C) therapeutic strategies for renal fibrosis. In the fibrotic kidney, the TGF-β/HGF ratio is out of balance, and TGF- 1 signaling dominates. Thus, therapeutic strategies should include a reduction of TGF-β activity and/or supplementation of HGF.

Plastic and Aesthetic Research
ISSN 2349-6150 (Online)   2347-9264 (Print)

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