fig3

Figure 3. Different stages of lipedema according to the size of the fat nodules in the subcutaneous tissue: (left) Stage 1 shows a thickening of the subcutaneous tissue with small palpable nodules; (middle) Stage 2 already shows bigger fatty nodules up to walnut-size; and (right) Stage 3 is defined by overhanging skin-fat lobules, especially in the medial knee area or the development of severe column legs with cuff sign