REFERENCES
4. Köse O, Waseem A. Keloids and hypertrophic scars: are they two different sides of the same coin? Dermatol Surg 2008;34:336-46.
5. SenCK, Roy S. Wound healing. In: Rodriguez E, Losee J, Neligan PC, editors. Plastic Surgery: Volume 3: Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery. 3rd ed. Philadelphia: Saunders; 2012. pp. 240-66.
6. Bennett JS, Berger BW, Billings PC. The structure and function of platelet integrins. J Thromb Haemost 2009;7:200-5.
7. Suzuki-Inoue K. Activation and inhibitory mechanisms of blood platelets. Nihon Rinsho 2014;72:1212-7.
8. He S, Blombäck M, Bark N, Johnsson H, Wallén NH. The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis. Thromb Haemost 2010;103:1076-84.
9. Marin V, Montero-Julian FA, Grès S, Boulay V, Bongrand P, Farnarier C, Kaplanski G. The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin. J Immunol 2001;167:3435-42.
10. Martins-Green M, Petreaca M, Wang L. Chemokines and their receptors are key players in the orchestra that regulates wound healing. Adv Wound Care 2013;2:327-47.
11. Sahni A, Odrljin T, Francis CW. Binding of basic fibroblast growth factor to fibrinogen and fibrin. J Biol Chem 1998;273:7554-9.
12. Tuan TL, Wu H, Huang EY, Chong SS, Laug W, Messadi D, Kelly P, Le A. Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. Am J Pathol 2003;162:1579-89.
13. Szpaderska AM, Egozi EI, Gamelli RL, DiPietro LA. The effect of thrombocytopenia on dermal wound healing. J Invest Dermatol 2003;120:1130-7.
14. Mirastschijski U, Jokuszies A, Vogt PM. Skin wound healing: repair biology, wound and scar treatment. In: Rodriguez E, Losee J, Neligan PC, editors. Plastic Surgery: Volume 3: Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery. 3rd ed. Philadelphia: Elsevier; 2012. pp. 268-96.
15. Roberts HR, Tabares AH. Overview of the coagulation reactions. In: High KA, Roberts HR, editors. Molecular basis of thrombosis and hemostasis. New York: Marcel Dekker; 1995. pp. 35-50.
16. Petreaca ML, Yao M, Liu Y, Defea K, Martins-Green M. Transactivation of vascular endothelial growth factor receptor-2 (VEGFR2) by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. MolBiol Cell 2007;18:5014-23.
17. Schraufstatter IU, Chung J, Burger M. IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways. Am J Physiol Lung Cell Mol Physiol 2001;280:1094-103.
18. Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006;6:173-82.
19. Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 2008;205:685-98.
20. Peters T, Sindrilaru A, HinzB, Hinrichs R, Menke A, Al-Azzeh EA, Holzwarth K, OreshkovaT, Wang H, Kess D, Walzog B, Sulyok S, Sunderkötter C, Friedrich W, Wlaschek M, Krieg T, Scharffetter-Kochanek K. Wound-healing defect of CD18 (-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation. EMBO J 2005;24:3400-10.
21. Simpson DM, Ross R. The neutrophilic leukocyte in wound repair: a study with antineutrophil serum. J Clin Invest 1972;51:2009-23.
23. DiPietro LA, Polverini PJ, Rahbe SM, Kovacs EJ. Modulation of JE/MCP-1 expression in dermal wound repair. Am J Pathol 1995;146:868-75.
24. Wetzler C, Kampfer H, Pfeilschifter J, Frank S. Keratinocyte-derived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo. Biochem Biophys Res Commun 2000;274:689-96.
25. Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 2005;15:599-607.
26. Novak ML, Koh TJ. Phenotypic transitions of macrophages orchestrate tissue repair. Am J Pathol 2013;183:1352-63.
27. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-25.
28. Eming SA, Werner S, Bugnon P, Wickenhauser C, Siewe L, Utermöhlen O, Davidson JM, Krieg T, Roers A. Accelerated wound closure in mice deficient for interleukin-10. Am J Pathol 2007;170:188-202.
29. Miao M, Yuan B, Mani R, Lu S. Macrophage activation dysfunction in impaired wound healing: a potential therapeutic target. Int J Low Extrem Wounds 2013;12:239-41.
30. Sindrilaru A, Scharffetter-Kochanek K. Disclosure of the culprits: macrophages-versatile regulators of wound healing. Adv Wound Care (New Rochelle) 2013;2:357-68.
31. Petreaca ML, Yao M, Ware C, and Martins-Green MM. Vascular endothelial growth factor promotes macrophage apoptosis through stimulation of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT). Wound Repair Regen 2008;16:602-14.
32. DiPietro LA. Wound healing: the role of the macrophage and other immune cells. Shock 1995;4:233-40.
33. Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975;78:71-100.
34. Martin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R, McKercher SR. Wound healing in the PU.1 null mouse-tissue repair is not dependent on inflammatory cells. Curr Biol 2003;13:1122-8.
35. Egozi EI, Ferreira AM, Burns AL, Gamelli RL, Dipietro LA. Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen 2003;11:46-54.
36. Khanna S, Biswas S, Shang Y, Collard E, Azad A, KauhC, Bhasker V, Gordillo GM, Sen CK, Roy S. Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 2010;5:e9539.
37. Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen 2008;16:70-9.
38. Li P, Liu P, Xiong RP, Chen XY, Zhao Y, Lu WP, Liu X, Ning YL, Yang N, Zhou YG. Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear. J Pathol 2011;223:659-71.
39. Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res 2010;107:1170-84.
40. Mirastschijski U, Impola U, Jahkola T, Karlsmark T, AGren MS, Saarialho-Kere U. Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds. Hum Pathol 2002;33:355-64.
41. Yager DR, Nwomeh BC. The proteolytic environment of chronic wounds. Wound Repair Regen 1999;7:433-41.
42. Enoch S, Grey JE, Harding KG. ABC of wound healing. Non-surgical and drug treatments. BMJ 2006;332:900-3.
43. Fray MJ, Dickinson RP, Huggins JP, Occleston NL. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem 2003;46:3514-25.
44. Shiota N, Nishikori Y, Kakizoe E, Shimoura K, Niibayashi T, ShimboriC, Tanaka T, Okunishi H. Pathophysiological role of skin mast cells in wound healing after scald injury: study with mast cell-deficient W/W (V) mice. Int Arch Allergy Immunol 2010;151:80-8.
45. Gallant-Behm CL, Hildebrand KA, Hart DA. The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs. Wound Repair Regen 2008;16:226-33.
47. Lund LR, Rømer J, Bugge TH, Nielsen BS, Frandsen TL, DegenJL, Stephens RW, Danø K. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J 1999;18:4645-56.
48. Mirastschijski U, Schnabel R, Claes J, Schneider W, Agren MS, Haaksma C, Tomasek JJ. Matrix metalloproteinase inhibition delays wound healing and blocks latent transforming growth factor-β1 promoted myofibroblast formation and function. Wound Repair Regen 2010;18:223-34.
49. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463-516.
50. Brix K, Dunkhorst A, Mayer K, Jordans S. Cysteine cathepsins: cellular roadmap to different functions. Biochimie 2008;90:194-207.
51. Gurtner GC. Wound healing: normal and abnormal. In: Thorne CH, Bartlett SP, Beasley RW, Aston SJ, Gurtner GC, Spear SL, editors. Grabb and Smith's Plastic Surgery. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. pp. 15-22.
52. Johnson KE, Wilgus TA. Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair. Adv Wound Care (New Rochelle) 2014;3:647-61.
53. Cao PF, Xu YB, Tang JM, Yang RH, Liu XS. HOXA9 regulates angiogenesis in human hypertrophic scars: induction of VEGF secretion by epidermal stem cells. Int J Clin Exp Pathol 2014;7:2998-3007.
54. Kazemi-Lomedasht F, Behdani M, Bagheri KP, Habibi-Anbouhi M, Abolhassani M, Arezumand R, Shahbazzadeh D, Mirzahoseini H. Inhibition of angiogenesis in human endothelial cell using VEGF specific nanobody. Mol Immunol 2015;65:58-67.
55. Li YJ, Li XH, Wang LF, Kuang X, Hang ZX, Deng Y, Du JR. Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice. Exp Eye Res 2014;129:119-26.
56. Mienaltowski MJ, Birk DE. Structure, physiology, and biochemistry of collagens. Adv Exp Med Biol 2014;802:5-29.
57. Nyström A, Velati D, Mittapalli VR, Fritsch A, Kern JS, Bruckner‑Tuderman L. Collagen VII plays a dual role in wound healing. J Clin Invest 2013;123:3498-509.
58. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002;3:349-63.
59. Desmoulière A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 2005;13:7-12.
60. Feugate JE, Li Q, Wong L, and Martins-Green M. The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J Cell Biol 2002;156:161-72.
61. Kato R, Kamiya S, Ueki M, Yajima H, Ishii T, Nakamura H, Katayama T, Fukai F. The fibronectin-derived antiadhesive peptides suppress the myofibroblastic conversion of rat hepatic stellate cells. Exp Cell Res 2001;265:54-63.
62. Darby IA, Laverdet B, Bonté F, Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol 2014;7:301-11.
63. Wall IB, Bhadal N, Broad S, Whawell SA, Mudera V, Lewis MP. Force generation and protease gene expression in organotypic co-cultures of fibroblasts and keratinocytes. J Tissue Eng Regen Med 2009;3:647-50.
64. Shah JM, Omar E, Pai DR, Sood S. Cellular events and biomarkers of wound healing. Indian J Plast Surg 2012;45:220-8.
66. Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 2007;127:998-1008.
67. Fu X, Xu M, Liu J, Qi Y, Li S, Wang H. Regulation of migratory activity of human keratinocytes by topography of multiscale collagen-containing nanofibrous matrices. Biomaterials 2014;35:1496-506.
68. Stevens LJ, Page-McCaw A. A secreted MMP is required for reepithelialization during wound healing. Mol Biol Cell 2012;23:1068-79.
69. Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. J Biol Chem 2001;276:29368-74.
70. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res 2004;299:465-75.
71. Mirastschijski U, Impola U, Karsdal MA, Saarialho-Kere U, Agren MS. Matrix metalloproteinase inhibitor BB-3103 unlike the serine proteinase inhibitor aprotinin abrogates epidermal healing of human skin wounds ex vivo. J Invest Dermatol 2002;118:55-64.
72. Frøssing S, Rønø B, Hald A, Rømer J, Lund LR. Skin wound healing in MMP2-deficient and MMP2/plasminogen double-deficient mice. Exp Dermatol 2010;19:e234-40.
73. Green KA, Almholt K, Ploug M, Rønø B, Castellino FJ, Johnsen M, Bugge TH, Rømer J, Lund LR. Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol 2008;128:2092-101.
74. Wojtowicz AM, Oliveira S, Carlson MW, Zawadzka A, Rousseau CF, Baksh D. The importance of both fibroblasts and keratinocytes in a bilayered living cellular construct used in wound healing. Wound Repair Regen 2014;22:246-55.
75. Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg 2006;117:S143-9.
76. Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 2002;6:127-33.
77. Greaves NS, Ashcroft KJ, Baguneid M, Bayat A. Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci 2013;72:206-17.
78. Kang HC Ahn SD, Choi DH, Kang MK, Chung WK, Wu HG. The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study. Radiat Oncol J 2014;32:156-62.
79. Singla S, Garg R, Kumar A, Gill C. Efficacy of topical application of beta urogastrone (recombinant human epidermal growth factor) in Wagner's Grade 1 and 2 diabetic foot ulcers: Comparative analysis of 50 patients. J Nat Sci Biol Med 2014;5:273-7.
80. Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 2014;22:569-78.
81. Toriseva M, Kahari VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci 2009;66:203-24.
82. Lau YK, Gobin AM, West JL. Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing. Ann Biomed Eng 2006;34:1239-46.
83. Gurtner GC, Wong VW. Wound healing: normal and abnormal. In: Thorne CH, Gurtner GC, Chung K, Gosain A, Mehrara B, Rubin P, Spear SL, editors. Grabb and Smith's Plastic Surgery. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2013. pp. 13-9.
84. Levenson SM, Geever EF, Crowley LV, Oates JF 3rd, Berard CW, Rosen H. The healing of rat skin wounds. Ann Surg 1965;161:293-308.
85. Witte MB, Thornton FJ, Kiyama T, Efron DT, Schulz GS, Moldawer LL, Barbul A. Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength. Surgery 1998;124:464-70.
86. Viera MH, Vivas AC, Berman B. Update on keloid management: clinical and basic science advances. Adv Wound Care (New Rochelle) 2012;1:200-6.
87. Rhett JM, Ghatnekar GS, Palatinus JA, O'Quinn M, Yost MJ, Gourdie RG. Novel therapies for scar reduction and regenerative healing of skin wounds. Trends Biotechnol 2008;26:173-80.
88. Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol 2000;157:423-33.
89. Järveläinen H, Puolakkainen P, Pakkanen S, Brown EL, Höök M, Iozzo RV, Sage EH, Wight TN. A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen 2006;14:443-52.
90. Occleston NL, O'Kane S, Goldspink N, Ferguson MW. New therapeutics for the prevention and reduction of scarring. Drug Discov Today 2008;13:973-81.
91. Wilgus TA. Regenerative healing in fetal skin: a review of the literature. Ostomy Wound Manage 2007;53:16-31.
92. King A, Balaji S, Le LD, Crombleholme TM, Keswani SG. Regenerative wound healing: the role of Interleukin-10. Adv Wound Care (New Rochelle) 2014;3:315-23.
93. Lo DD, Zimmermann AS, Nauta A, Longaker MT, Lorenz HP. Scarless fetal skin wound healing update. Birth Defects Res C Embryo Today 2012;96:237-47.
94. Wulff BC, Parent AE, Meleski MA, DiPietro LA, Schrementi ME, Wilgus TA. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol 2012;132:458-65.
95. Penn JW, Grobbelaar AO, Rolfe KJ. The role of the TGF-β family in wound healing, burns and scarring: a review. Int J Burns Trauma 2012;2:18-28.
96. Koźlik M, Wójcicki P. The use of stem cells in plastic and reconstructive surgery. Adv Clin Exp Med 2014;23:1011-17.
97. da Silva Meirelles L, Caplan AI, Nardi NB. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008;26:2287-99.
98. Uysal CA, Tobita M, Hyakusoku H, Mizuno H. The Effect of Bone-Marrow-Derived Stem Cells and Adipose-Derived Stem Cells on Wound Contraction and Epithelization. Adv Wound Care (New Rochelle) 2014;3:405-13.
99. Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol 2011;6:457-78.
100. Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, Shrayer D, Carson P. Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 2007;13:1299-312.
