Topic: Advances in Genetic and Hormonal Therapies for XXY (Klinefelter) Syndrome

Klinefelter syndrome, also known as XXY syndrome, is a genetic condition where males are born with an extra X chromosome, leading to a variety of physical, developmental, and reproductive challenges. This condition affects approximately 1 in 500 to 1,000 newborn males and is often underdiagnosed or misdiagnosed due to its subtle and varied presentation.

Recent advances in genetic and hormonal therapies have brought new hope for managing and potentially mitigating the symptoms associated with XXY syndrome. Genetic therapies are exploring the possibilities of correcting or compensating for the chromosomal anomaly at the molecular level, while hormonal treatments focus on addressing the androgen deficiency and its associated symptoms, such as reduced muscle mass, low energy levels, and infertility.

This Special Issue aims to consolidate the latest research, reviews, and clinical perspectives on the innovative approaches being developed for the management of XXY syndrome. It will explore the potential of gene therapy, advancements in testosterone replacement therapy, and the role of early intervention in improving long-term outcomes for individuals with this condition. By providing a platform for these discussions, we aim to accelerate the translation of scientific discoveries into clinical practice, ultimately improving the quality of life for those affected by XXY syndrome.