Topic: Biological Determinants and Lifestyle Modulators of Cardiovascular Aging

This Special Issue of The Journal of Cardiovascular Aging, titled "Biological Determinants and Lifestyle Modulators of Cardiovascular Aging," explores the intricate interplay between intrinsic biological processes and extrinsic lifestyle factors in shaping cardiovascular health across the lifespan. As cardiovascular disease remains the leading cause of morbidity and mortality in older adults, understanding the mechanisms that drive cardiovascular aging is critical for developing effective, targeted interventions. This issue brings together cutting-edge research on cellular and molecular changes—such as inflammation, oxidative stress, mitochondrial dysfunction, and vascular remodeling—that underlie age-related cardiovascular decline. In parallel, it highlights the modulatory role of lifestyle factors, including physical activity, nutrition, sleep quality, stress management, and social engagement. The contributions examine how these behaviors may mitigate or exacerbate biological aging processes, offering valuable insights into both preventive and therapeutic strategies. The collection also considers the influence of sex, genetics, and comorbidities, as well as translational approaches that bridge basic science with clinical practice. Through this integrative lens, the issue aims to advance our understanding of cardiovascular aging and inspire multidisciplinary collaboration to promote healthier aging trajectories.

Hallmarks of aging, pillars of aging, lifestyle interventions, vascular function, endothelial function, arterial stiffness, oxidative stress, inflammation