fig4

Figure 4. Time x Treatment interaction for changes in (A) CGI-Improvement rated by clinicians; and (B) VAS “Restricted interests” rated by parents. For both variables, active compound produces significantly greater improvement when administered during Period II, but not during Period I. CGI-I scores: 1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Minimally worse, 6 = Very much worse.*P< 0.05.