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![Biallelic cubilin pathogenic variants as a cause of « benign » proteinuria: implications for clinical management](https://image.oaes.cc/77bdbe71-ca26-430c-a556-eaf3f3e93beb/5699.fig.2.jpg)
Figure 2. Cubilin protein structure. Cubilin (CUB) is a 460 kDa glycoprotein without transmembrane domain. It acts as a receptor for intrinsic factor-vitamin B12 complexes. There are 27 CUB domains. Intrinsic factor and vitamin B12 binding region is located in domains 5 to 8. The precise location of the binding sites for albumin remains unclear, but it is supposed to be located in the CUB domains near the C-terminal area. IGS : Imerslund-Grasbëck syndrome; IF : intrinsic factor.