fig3

From: PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology

Figure 3. Enzymatic activity of PNPLA3. PNPLA3 is an important protein that catalyzes crucial reactions in lipid metabolism. It primarily catalyzes three reactions: PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology acting as a triacylglycerol lipase, functioning as a phospholipase A₂ by removing the fatty acid attached to the 2-position of phosphatidylethanolamine, choline plasmalogen, and phosphatides, and PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology specifically catalyzing coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid) to generate phosphatidic acid.