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![The potential therapeutic applications of long non-coding RNAs](https://image.oaes.cc/6475af3d-2007-47a7-a9ea-f9034d3b4231/jtgg4012.fig.4.jpg)
Figure 4. Schematic illustration of the functional mechanism of guide lncRNAs. Guide lncRNAs function by guiding proteins (labelled “p”) to localise to specific targets in cis or trans, resulting in changes in gene expression. These effects can include activation or repression of genes depending on the specific protein.