fig3

Figure 3. A summary of the potential cellular mechanisms of secondary mitochondrial dysfunction in LSDs/Alpha-Mannosidosis. The diagram depicted illustrates the putative cellular mechanism of secondary mitochondrial dysfunction in AM and other LSDs. RER: Rough endoplasmic reticulum; ROS: reactive oxygen species; AM enzyme: Alpha-Mannosidase enzyme; MRO: mannose-rich oligosaccharides; ATP: adenosine triphosphate.