fig2

Figure 2. Schematic view of target proteins for immunotherapy, mostly expressed and over-expressed in prostate cancer. Prostate cancer mostly expressed target proteins for immunotherapy such as prostate-specific antigen (PSA), PSMA (prostate-specific membrane antigen), prostatic acid phosphatase, PSCA (Prostate stem cell antigen), dMMR (DNA mismatch repair deficiency), MSI-H (microsatellite instability), TMB-H (high tumor mutational burden), prostein, TARP (T-cell receptor gamma alternate reading frame protein), Transient receptor potential melastatin 8 (Trp-p8), six transmembrane epithelial antigen of prostate-1 (STEAP1), NY-ESO-1 and overexpressed proteins such as parathyroid hormone-related protein, human telomerase reverse transcriptase (hTERT), survivin, HER-2/neu, EGFR, HER-4 (Epidermal Growth Factor Family), EphA2 (Erythropoietin producing hepatocellular receptor tyrosine kinase class A2), SSX (Synovial sarcoma X-chromosome break point protein), EpCAM(epithelial cell adhesion molecule), RIPK2 (receptor-interacting protein kinase 2).