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Figure 1. Immune Evasion in Prostate Cancer, the inhibitory effect of MDSCs, Tregs, and TAMs on effector T-cell functions. The activated T Cells (aATCs) with bispecific antibodies target MDSCs and inhibit their suppressive function and show the inhibition of MDSC-associated enzymes and the release of cytokines and chemokines. Therapeutic approaches such as vaccines and therapeutic agents (imatinib, sunitinib, cyclophosphamide, gemcitabine) target the immunosuppressive microenvironment. The Th17 cells producing IL-17 as pro-inflammatory cells and the frequency of CCR4/IL-17/CD4+ T cells in prostate cancer patients increases the immunotherapy and antitumor response. Negative costimulatory ligands (PDL-1, CTLA-4), regulatory lymphocytes, myeloid cells, and immunosuppressive substances (IL-10, TGF-β, IDO) show inhibitory effects on immune cells.