fig1
From: What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia?
![What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia?](https://image.oaes.cc/07a7ba94-25fd-4292-96f9-87955f5763c2/jtgg8039.fig.1.jpg)
Figure 1. The cascade of reactions involved in the UPS. (A) The ubiquitination cascade involves the E1, E2, and E3 ubiquitin ligases and produces a polyubiquitinated end-product. (B) The polyubiquitinated protein is then located by the proteasome which degrades and deubiquitinates the protein. Created with BioRender.com.