fig2

Figure 2. The effect of mitochondrial dynamics modifiers on the processes of mitochondrial biogenesis. Metformin and AICAR act on AMPK by activating PGC-1a, and consequently suppress inflammatory processes, inhibit TNF–NF-Kb, and also stimulate the processes of mitophagy and biogenesis. Fenofibrate and bezafibrate activate PPARa, stimulating the processes of mitophagy and mitochondrial biogenesis, by activating UCP-2 and CPT-1. Epicatechin, acting on TFAM, activates mitochondrial biogenesis. Resveratrol activates SIRT1 and PGC-1a, stimulating the processes of mitophagy and mitochondrial biogenesis. SRT2104, Statins, and RTA-408 suppress inflammatory activity by inactivating NLRP3 through the inhibition of NF-kB. SRT2104 and RTA-408 stimulate the process of mitophagy and mitochondrial biogenesis by activating SIRT1 and NRF-2 correspondingly.