fig3
From: Towards an understanding of the aetiology, genomic landscape and management of Moebius syndrome
Figure 3. Multifactorial aetiology of MBS. (A) Represents an axial section of the brainstem at the level of the facial colliculus, illustrating the abducent (CNVI) and facial (CNVII) nuclei and motor neurons, as present in typical development. (B) Illustrates how multifactorial insults in early embryonic development can result in hypoplastic CNVI and CNVII nuclei and/or reduced number of CNVI and CNVII motor neurons, resulting in the key clinical manifestations of MBS.
