fig3
![Potential therapeutic response in a severe case of autosomal dominant osteopetrosis type I](https://image.oaes.cc/8ca663df-4607-42af-9fca-458f58f6c836/4941.fig.3.jpg)
Figure 3. Cranial volume and tonsillar descent measurements. (A-B) Intracranial bone volume was measured by CT scan-based 3D reconstruction. (A) The software outlined the patient’s intracranial space in 5 to 10 slices of each CT scan. (B) The software calculates volume using the outlined area and slice thickness. (C-F) Serial CT scans were used to measure the descent of the cerebellar tonsil. (A-F) Measurements performed on CT scans taken during leuprolide acetate treatment are shown in gray. CT: Computed tomography.