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![Developmental and epileptic encephalopathies after negative or inconclusive genetic testing: what is next?](https://image.oaes.cc/cfdcf477-ed42-4863-8f30-d0bd462cf543/4433.fig.1.jpg)
Figure 1. Diagram depicting the concepts of “direct genetics”, i.e., the “genotype to phenotype” approach; “reverse genetics”, i.e., the analysis of the impact of an induced variation in a specific gene for a gene function with different techniques (CRISPR/Cas, etc.); and “reverse phenotyping”, i.e., the clinical assessment driven by genetic results. siRNA: small interfering RNA.