fig3

Figure 3. mRNA expression. Identification of differential expression of mRNA gene signatures and associated (A) cellular, (B) cell signaling, and (C) immune pathways, comparing initial biopsy specimens (n = 19) to brain tissue controls (n = 3). Identification of differential expression of mRNA gene signatures and associated with (D) cellular, (E) cell signaling, and (F) immune pathways, comparing the six matched patient samples before and after M032 treatment [Table 3]. Gene expression is grouped according to mRNA function and represented as pathway scores where > 0 indicates upregulation in tumor tissue and < 0 indicates downregulation in tumor tissue compared to normal. Statistical significance between groups was evaluated by two-way ANOVA with correction for multiple comparisons using Holm-Sidak *P < 0.05 and **P < 0.01.