fig3
![Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1](https://image.oaes.cc/96b8665f-18b5-4bfa-9545-16d3d9c6b0d5/4073.fig.3.jpg)
Figure 3. Kavalactones inhibits MAO-A enzyme activity. (A, B) Kawain and methysticin were docked with MAO-A protein by Autodocktools program, and the superimposed binding of kawain and methysticin to MAO-A, respectively, was observed in Pymol program. 2D molecular structures of kawain and methysticin are shown to interact with key amino acids on the predicted binding site. (C) MAO-A enzyme activities were analyz ed in prostate cancer C4-2B and LNCaP cell lysates after treatment with 0.1% DMSO (control), KRE and kavalactones for 24 h. MAO-A: Monoamine oxidase A; KRE: kava root extract. *P < 0.05.