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Figure 2. Dietary feeding of the KRE reduces tumorigenesis in TRAMP mice. (A) Upper panel, schematic presentation of intervention protocol by the KRE in the TRAMP model. Lower panel, average GU weights in different treatment groups. **P < 0.01. (B) Percentages of mice with large tumor formation. *P < 0.05 and **P < 0.01. (C) 0.6% KRE food results in a reduction of food consumption over time. (D) Dietary feeding of 0.3% and 0.6% KRE food reduces mean body weight gain of TRAMP mice over time. KRE: Kava root extract; TRAMP: transgenic adenocarcinoma of the mouse prostate; GU: genitourinary.