fig1

Figure 1. Timeline highlighting historical milestones in the understanding of SMZL. HPLL refers to the determinant factors in the stratification model (haemoglobin, platelet count, high lactate dehydrogenase, and lymphadenopathy) and the three groups patients are grouped in (A, B and C). NGS: Next generation sequencing; CBL-MZ: clonal B-cell lymphocytosis of marginal zone origin; MZ: marginal zone; IGHV: immunoglobulin heavy chain variable region; WGS: whole genome sequencing; WES: whole exome sequencing; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; LDH: lactate dehydrogenase; HCV: hepatitis C virus; WHO: World Health Organisation; SMZL: splenic marginal zone lymphoma. Additional references^[11-19].