fig2
![Hydroxyurea treatment of sickle cell disease: towards a personalized model-based approach](https://image.oaes.cc/6c7730af-8c65-4eff-b8fd-422c754344e7/3834.fig.2.jpg)
Figure 2. A modeling framework for optimal dose calculation. D(t): HU dose; yp:HU plasma concentration; ym: metabolite concentration; HbF: fetal hemoglobin concentration; MCV: mean cell volume of red blood cell; ANC: absolute neutrophil count; ARC: absolute reticulocytes count