fig1
![Hydroxyurea treatment of sickle cell disease: towards a personalized model-based approach](https://image.oaes.cc/6c7730af-8c65-4eff-b8fd-422c754344e7/3834.fig.1.jpg)
Figure 1. Proposed hydroxyurea signaling pathway. HU: hydroxyurea; NO: nitric oxide; sGC: soluble guanylyl cyclase; GTP: guanosine triphosphate; cGMP: cyclic guanosine monophosphate; p38 MAPK: p38 mitogen-activated protein kinase; TFr: repressor; solid line: activation; dashed line: repression; asterisk: activated form