fig1

Hydroxyurea treatment of sickle cell disease: towards a personalized model-based approach

Figure 1. Proposed hydroxyurea signaling pathway. HU: hydroxyurea; NO: nitric oxide; sGC: soluble guanylyl cyclase; GTP: guanosine triphosphate; cGMP: cyclic guanosine monophosphate; p38 MAPK: p38 mitogen-activated protein kinase; TFr: repressor; solid line: activation; dashed line: repression; asterisk: activated form

Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
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