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![The somatic clinico-genomics of localized, non-indolent prostate cancer](https://image.oaes.cc/34e6e262-bc8b-4fbe-86a1-7c61208aaf84/2925.fig.1.jpg)
Figure 1. Schematic of androgen-driven ERG expression following TMPRSS2:ERG fusion. Fusion of the 5’ regulatory region of the TMPRSS2 gene (21q22.3) - including an upstream androgen response element (ARE) - to the coding region of the ERG oncogene (21q22.2) results in a fusion product in which ERG expression is induced in an androgen-responsive manner. This fusion can be detected using fluorescence in situ hybridization[28] or indirectly through ERG immunohistochemistry